Founded in 1921 as a University College, the University of Leicester (ULEIC) is one of the leading universities in the United Kingdom committed to international excellence through research and teaching. Core research areas are bioanalytical chemistry, functional materials, polymers and molecularly imprinted polymers (MIPs), computational design and molecular modelling, nanoparticles for diagnostics and therapeutic applications, as well as biotechnology and biopharmaceuticals. The university comprises a team of chemists, engineers and biologists, all working closely together in a state-of-the-art facility.
The ULEIC team will contribute to the CureCN project with its expertise in design and preparation of molecularly imprinted polymers which will be used as recognition elements in a novel, polymer-based anti-AAV Ig-specific plasmapheresis resin to selectively remove NAbs from the bloodstream of seropositive subjects. Hypervariable regions of anti-AAV antibodies will be used as templates to synthesize nanoMIPs complexes, which will be digested under partial proteolysis. A prototype column will be developed in collaboration with Genethon using resins suitable for clinical development.
Staff members involved
Kal KarimTeam Member
